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Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

《医学前沿（英文）》 2021年 第15卷 第3期   页码 438-447 doi: 10.1007/s11684-020-0826-1

摘要： Thoracic aortic dissection (TAD) without familial clustering or syndromic features is known as sporadic TAD (STAD). So far, the genetic basis of STAD remains unknown. Whole exome sequencing was performed in 223 STAD patients and 414 healthy controls from the Chinese Han population (N = 637). After population structure and genetic relationship and ancestry analyses, we used the optimal sequence kernel association test to identify the candidate genes or variants of STAD. We found that COL3A1 was significantly relevant to STAD (P = 7.35 × 10−6) after 10 000 times permutation test (P = 2.49 × 10−3). Moreover, another independent cohort, including 423 cases and 734 non-STAD subjects (N = 1157), replicated our results (P = 0.021). Further bioinformatics analysis showed that COL3A1 was highly expressed in dissected aortic tissues, and its expression was related to the extracellular matrix (ECM) pathway. Our study identified a profile of known heritable TAD genes in the Chinese STAD population and found that COL3A1 could increase the risk of STAD through the ECM pathway. We wanted to expand the knowledge of the genetic basis and pathology of STAD, which may further help in providing better genetic counseling to the patients.

关键词： sporadic thoracic aortic dissection     exome sequencing     gene COL3A1     case–control study     extracellular matrix    

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U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-controlstudy in Chinese population

null

《医学前沿（英文）》 2015年 第9卷 第4期   页码 478-486 doi: 10.1007/s11684-015-0420-0

摘要：

Telomeres play a critical role in biological ageing by maintaining chromosomal integrity and preventing chromosome ends fusion. Epidemiological studies have suggested that inter-individual differences of telomere length could affect predisposition to multiple cancers, but evidence regarding esophageal squamous cell carcinoma (ESCC) was still uncertain. Several telomere length-related single nucleotide polymorphisms (TL-SNPs) in Caucasians have been reported in genome-wide association studies. However, the effects of telomere length and TL-SNPs on ESCC development are unclear. Therefore, we conducted a case-control study (1045 ESCC cases and 1433 controls) to evaluate the associations between telomere length, TL-SNPs, and ESCC risk in Chinese population. As a result, ESCC cases showed overall shorter relative telomere length (RTL) (median: 1.34) than controls (median: 1.50, P<0.001). More interestingly, an evident nonlinear U-shaped association was observed between RTL and ESCC risk (P<0.001), with odds ratios (95% confidence interval) equal to 2.40 (1.84–3.14), 1.36 (1.03–1.79), 1.01 (0.76–1.35), and 1.37 (1.03–1.82) for individuals in the 1st (the shortest), 2nd, 3rd, and 5th (the longest) quintile, respectively, compared with those in the 4th quintile as reference group. No significant associations were observed between the eight reported TL-SNPs and ESCC susceptibility. These findings suggest that either short or extremely long telomeres may be risk factors for ESCC in the Chinese population.

关键词： esophageal squamous cell carcinoma     telomere length     genetic variants     susceptibility     genome-wide association study    

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锑元素与先天性心脏病关系的病例对照研究

林元,陈小玲,林晓文,刘敏,徐两蒲,何德钦,高丽素

《中国工程科学》 2014年 第16卷 第5期   页码 73-78

摘要：

采用以院为基础的病例对照研究，在福建省妇幼保健院(三级甲等医院)募集新近发生的69 例胎儿先天性心脏病病例，以1∶1 配对的方法设立对照组，采用电感耦合等离子体质谱仪分析方法，测定病例组和对照组孕妇孕期头发中锑、锌、铜、铁、铅等元素的含量，并问卷调查孕早期危险因素的暴露情况，用SPSS19.0 Cox 比例风险模型进行流行病学多因素分析。孕妇发锑含量偏高(相对危险度的比值比(OR) =33.833；95 %可信区间(CI)：4.060～281.929)、孕期使用不锈钢餐具(OR=8.981，95 % CI：1.085～74.327)、居所周围50 m有马路(OR=11.067，95 % CI：1.025～119.521)是先天性心脏病的危险因素。孕期锑负荷增加可能是先天性心脏病的原因之一。

关键词： 先天性心脏病     锑元素     病例对照研究     调查问卷    

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EXPLORING THE RECYCLING OF MANURE FROM URBAN LIVESTOCK FARMS: A CASE STUDY IN ETHIOPIA

《农业科学与工程前沿（英文）》 2021年 第8卷 第1期

摘要：

• Livestock manure was the main organic waste in urban and peri-urban areas.

• Manure production will increase by a factor of 3–10 between 2015–2050.

• Only 13%–38% of excreted N by livestock will be recycled in croplands.

• Intensification of urban livestock production greatly increased N surpluses.

• Reducing population growth and increasing livestock productivity needed.

 

Urban population growth is driving the expansion of urban and peri-urban agriculture (UPA) in developing countries. UPA is providing nutritious food to residents but the manures produced by UPA livestock farms and other wastes are not properly recycled. This paper explores the effects of four scenarios: (1) a reference scenario (business as usual), (2) increased urbanization, (3) UPA intensification, and (4) improved technology, on food-protein self-sufficiency, manure nitrogen (N) recycling and balances for four different zones in a small city (Jimma) in Ethiopia during the period 2015-2050. An N mass flow model with data from farm surveys, field experiments and literature was used. A field experiment was conducted and N use efficiency and N fertilizer replacement values differed among the five types of composts derived from urban livestock manures and kitchen wastes. The N use efficiency and N fertilizer replacement values were used in the N mass flow model.

Livestock manures were the main organic wastes in urban areas, although only 20 to 40% of animal-sourced food consumed was produced in UPA, and only 14 to 19% of protein intake by residents was animal-based. Scenarios indicate that manure production in UPA will increase 3 to 10 times between 2015 and 2050, depending on urbanization and UPA intensification. Only 13 to 38% of manure N will be recycled in croplands. Farm-gate N balances of UPA livestock farms will increase to>1 t·ha−1 in 2050. Doubling livestock productivity and feed protein conversion to animal-sourced food will roughly halve manure N production.

Costs of waste recycling were high and indicate the need for government incentives. Results of these senarios are wake-up calls for all stakeholders and indicate alternative pathways.

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FULL TIME-SPACE GOVERNANCE STRATEGY AND TECHNOLOGY FOR CROPLAND NON-POINT POLLUTION CONTROL IN CHINA

《农业科学与工程前沿（英文）》 2023年 第10卷 第4期   页码 593-606 doi: 10.15302/J-FASE-2023522

摘要：

Ensuring food safety while reducing agricultural non-point source pollution is quite challenging, especially in developing and underdeveloped countries. Effective systematic strategies and comprehensive technologies need to be developed for agricultural non-point source pollution control at the watershed scale to improve surface water quality. In this review, a proposal is made for a full time-space governance strategy that prioritizes source management followed by endpoint water pollution control. The 4R chain technology system is specifically reviewed, including source reduction, process retention, nutrient reuse and water restoration. The 4R chain technology system with the full time-space governance strategy was applied at the scale of an administrative village and proved to be a feasible solution for reducing agricultural non-point source pollution in China. In the future, a monitoring system needs to be established to trace N and P transport. Additionally, new smart fertilizer and intelligent equipment need to be developed, and relevant governance standards and supportive policies need to be set to enhance the efficacy of agricultural non-point source pollution control.

关键词： 4R chain technology system     agricultural non-point source pollution     case study     full time-space governance strategy    

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Microplastics in municipal wastewater treatment plants: a case study of Denizli/Turkey

《环境科学与工程前沿（英文）》 2023年 第17卷 第8期 doi: 10.1007/s11783-023-1699-8

摘要：

● High amounts of microplastics are released to receiving media from WWTPs.

关键词： Microplastics     Wastewater treatment plant     Removal efficiency     Daily discharge    

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Efficiency evaluation of government investment for air pollution control in city clusters: A case from

《工程管理前沿（英文）》   页码 612-624 doi: 10.1007/s42524-023-0269-x

摘要： Air pollution poses a significant threat to human health, particularly in urban areas with high levels of industrial activities. In China, the government plays a crucial role in managing air quality through the Air Pollution Prevention and Control Action Plan. The government provides direct financial support and guides the investment direction of social funds to improve air quality. While government investment has led to improvements in air quality across China, concerns remain regarding the efficiency of such large-scale investments. To address this concern, we conducted a study using a three-stage data envelopment analysis (DEA)-Malmquist model to assess the efficiency of government investment in improving air quality in China. Our analysis revealed regional disparities and annual dynamic changes. Specifically, we focused on the Beijing–Tianjin–Hebei areas as a case study, as the investment primarily targeted industrial activities in urban areas with the goal of improving living conditions for urban residents. The results demonstrate significant differences in investment efficiency between regions. Beijing exhibits relatively high investment efficiency, while cities in Hebei Province require improvement. We identified scale inefficiency, which refers to the ratio of air pollutant reduction to financial investment, as the main factor contributing to regional disparities. However, we found that increasing the total investment scale can help mitigate this effect. Furthermore, our study observed positive but fluctuating annual changes in investment efficiency within this city cluster from 2014 to 2018. Investment-combined technical efficiency, which represents the investment strategy, is the main obstacle to improving yearly investment efficiency. Therefore, in addition to promoting investment strategies at the individual city level, it is crucial to enhance coordination and cooperation among cities to improve the investment efficiency of the entire city cluster. Evaluating the efficiency of government investment and understanding its influencing factors can guide future investment measures and directions. This knowledge can also support policymaking for other projects involving substantial investments.

关键词： investment efficiency     government investment     air pollution control     three-stage DEA-Malmquist model    

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Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study

《环境科学与工程前沿（英文）》 2023年 第17卷 第9期 doi: 10.1007/s11783-023-1716-y

摘要：

● A systematic framework was developed to identify i-PPCPs for landfill leachate.

关键词： Landfill leachates     PPCPs     Indicator     Screening criteria     Source-specificity    

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Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-controlstudy in Han Chinese people

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

《医学前沿（英文）》 2010年 第4卷 第1期   页码 90-95 doi: 10.1007/s11684-010-0021-x

摘要： This study aimed to identify functional single nucleotide polymorphisms in the cyclooxygenase-2 gene promoter and evaluate their effects on the risk of primary hepatocellular carcinoma (HCC) with hepatitis B virus (HBV) infection. We conducted a population-based, case-control study enrolling 630 Han Chinese people in Hubei province. Subjects included primary HCC patients with HBV infection (=210), chronic hepatitis B cases (=210) and healthy Han Chinese (=210). -1195G/A polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and sequencing analysis. We found-1195A allele carriers had a higher risk of HCC with HBV infection (OR, 0.72; 95% CI, 0.548–0.946). The-1195A allele might be used as a marker in screening individuals at high risk of HCC with HBV infection.

关键词： cyclooxygenase-2 gene     single nucleotide polymorphisms     susceptibility     primary hepatocellular carcinoma     hepatitis B virus infection    

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Comparison of indirect boundary element and finite element methods A case study: Shiraz-Esfahan railway

Amin MANOUCHEHRIAN, Mohammad Fatehi MARJI, Mohsen MOHEBBI

《结构与土木工程前沿（英文）》 2012年 第6卷 第4期   页码 385-392 doi: 10.1007/s11709-012-0173-7

摘要： Because of the high importance of transportation tunnels, most precise analyses of stress concentration and displacement around them are essential to provide safety of them as much as possible. Recently, various numerical methods such as finite element method (FEM), discrete element method (DEM), finite difference method (FDM) and boundary element method (BEM) have been used extremely in geosciences problems, but among these numerical methods, BEM has been used less than others because the computational algorithm is not so straightforward. This paper suggests the implementation of the indirect boundary element method (IBEM) as a formulation of BEM to analyze displacement around Shiraz-Esfahan railway tunnel in Zagros Mountains southwest of Iran. For this purpose, this tunnel has been modeled numerically using two-dimensional fictitious stress method (TWOFS) algorithm. To validate the results, they were compared with FEM results as a commonly used numerical method. Results of current theoretical study have shown that the presented approach using IBEM is reasonably accurate and can be used for analysis of displacement in geosciences problems. In rock mechanics, for problems with a low ratio of boundary surface to volume, FEM is not very well suited and may be cumbersome, but use of such a proposed IBEM approach can be particularly attractive.

关键词： indirect boundary element method     finite element method     displacement     tunnel     case study    

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Classification and quantification of excavated soil and construction sludge: A case study in Wenzhou,

《结构与土木工程前沿（英文）》 2022年 第16卷 第2期   页码 202-213 doi: 10.1007/s11709-021-0795-8

摘要： With rapid urbanization in China, a large amount of excavated soil and construction sludge is being generated from geotechnical and underground engineering. For sustainable management of these construction wastes, it is essential to quantify their production first. The present study has attempted to classify the excavated soil and construction sludge according to their composition and geotechnical properties (particle size, water content, plasticity index). Based on these classifications, a new approach was proposed to quantify the production. The said approach was based on multi-source information, such as the urban topographic map, geological survey reports, urban master plan, and remote sensing images. A case study in Wenzhou city of China was also pursued to illustrate the validity of the newly developed approach. The research showed that in 2021–2025, the total excavated soils and construction sludge production in Wenzhou would reach 107.5 × 106 and 81.7 × 106 m3, respectively. Furthermore, the excavated soil was classified into the miscellaneous fill, crust clay, muddy clay and mud with silty sand. Likewise, the construction sludge was classified as liquid sludge and paste-like sludge. The classification and quantification can serve as guidance for disposal and recycling, thereby leading to high-level management of waste disposal.

关键词： excavated soil     construction sludge     geotechnical and underground engineering     production     classification    

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Pavement sustainability index for highway infrastructures: A case study of Maryland

Stella O. OBAZEE-IGBINEDION, Oludare OWOLABI

《结构与土木工程前沿（英文）》 2018年 第12卷 第2期   页码 192-200 doi: 10.1007/s11709-017-0413-y

摘要： Pavement deterioration creates conditions that undermine their performances, which gives rise to the need for maintenance and rehabilitation. This paper develops a mathematical multi-linear regression analysis (MLRA) model to determine a pavement sustainability index ( ) as dependent variable for flexible pavements in Maryland. Four categories of pavement performance evaluation indicators are subdivided into seven pavement condition indices and analyzed as independent variables for each section of pavement. Data are collected from five different roadways using field evaluations and existing database. Results indicate that coefficient of determination ( ) is correlated and significant, = 0.959. Of the seven independent variables, present serviceability index ( ) is the most significant with a coefficient value of 0.032, present serviceability rating ( ) coefficient value= 0.028, and international roughness index ( ) coefficient value= ?0.001. Increasing each unit value of coefficients for and would increase the value of ; thereby providing a more sustainable pavement infrastructure; which explains the significance of the model and why will most likely impact environmental, economic and social values.

关键词： pavement indices     sustainability     pavement performance     flexible pavements    

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Supplier development and its incentives in infrastructure mega-projects: A case study on Hong Kong-Zhuhai-Macao

Wei ZENG, Jinwen ZHANG, Hongwei WANG, Hongtao ZHOU

《工程管理前沿（英文）》 2018年 第5卷 第1期   页码 88-97 doi: 10.15302/J-FEM-2018077

摘要： In this paper the Hong Kong-Zhuhai-Macao Bridge project is taken as a case to analyze supplier development in infrastructure mega-projects. Compared with manufacturing industry, the characteristics of supplier development in infrastructure mega-projects is analyzed in term of development motives, supplier selection, quality management, production mode, owner participation and risks. The critical factors influencing the construction supplier development are identified, which include incentives, collaboration, future market, trust and bilateral communication. Furthermore, focusing on the incentives for the supplier’s product quality and production capacity improvement, decision-making framework models are proposed to design the incentive mechanisms.

关键词： infrastructure mega-project     supplier development     critical success factors     incentives     case study    

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Investigating the effect of online and offline reputation on the provision of online counseling services: A casestudy of the Internet hospitals in China

《工程管理前沿（英文）》   页码 563-576 doi: 10.1007/s42524-022-0198-0

摘要： The sustainable development of Internet hospitals and e-health platforms relies on the participation of patients and physicians, especially on the provision of health counseling services by physicians. The objective of our study is to explore the factors motivating Chinese physicians to provide online health counseling services from the perspectives of their online and offline reputation. We collect the data of 141029 physicians from 6173 offline hospitals located in 350 cities in China. Based on the reputation theory and previous studies, we incorporate patients’ feedback as physicians’ online reputation and incorporate physicians’ offline professional status as physicians’ offline reputation. Results show that physicians’ online reputation significantly and positively influence their online counseling behaviors, whereas physicians’ offline reputation significantly and negatively influence their online counseling behaviors. We conclude that physician’s online and offline reputations show a competitive and substitute relationship rather than a complementary relationship in influencing physicians to provide online counseling services in Internet hospitals. One possible explanation for the substitute relationship could be the constraints of limited time and effort of physicians.

关键词： Internet hospitals     physicians’ online counseling     online reputation     offline reputation    

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Causations of failure in megaprojects: A case study of the Ajaokuta Steel Plant project

Oluwole Alfred OLATUNJI

《工程管理前沿（英文）》 2018年 第5卷 第3期   页码 334-346 doi: 10.15302/J-FEM-2018011

摘要：

This paper uses project organizational theories to draw lessons from a historic megaproject, the Ajaokuta Steel Plant (ASP). Archival reports on the ASP were explored to identify the unique attributes of the project; the political wrangling that underplayed its evolution, its economic significance and organizational impacts. Findings suggest the goals of the ASP project were, and still are, unambiguous. Failure occurred as socio-political forces aggravated the project’s complex milestones. Stakeholders were impatient with pre-project investigations. During planning, owners ignored opinions that were contrary to their expectations. While delays lingered, pressures from the global economy weakened the project’s motivation to succeed. These combined to turn the project’s outcomes into a chaotic situation that triggered dire implications. Despite about 1400% overrun in cost, the success achieved on the plant was 28% at commissioning. Contractors remained on site until eight years after commissioning. Six key elements of the 482 items in the ASP project contract were not delivered nearly 40 years on. A simplistic look at these suggests poor planning is the main problem. However, planning issues is not entirely strange in greenfield projects. The paper draws strength from project organization theories to explain what was poor about the planning. Socrates’ generic management theory was used to explain the role of leadership in the failure of the ASP project. McGregor’s Theory X and Theory Y explain the significance of stakeholders’ integration in megaprojects. Systems and chaos theories were used to explain the sensitivity of the ASP project to uncertainties. Narratives on these combine well to inspire stakeholders of megaprojects on where and how to seek courage in making effective plans that can help achieve success in complex projects. While normative literature only recognizes project success in a definitive perspective, this study provides insights from failure as an instrument to trigger sublime reflections.

关键词： industrial projects     megaprojects     Nigeria     project organizational theories     steel plant    

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标题 作者 时间 类型 操作

Identification of variants associated with sporadic thoracic aortic dissection: a case--control study

期刊论文

U-shaped association between telomere length and esophageal squamous cell carcinoma risk: a case-controlstudy in Chinese population

null

期刊论文

锑元素与先天性心脏病关系的病例对照研究

林元,陈小玲,林晓文,刘敏,徐两蒲,何德钦,高丽素

期刊论文

EXPLORING THE RECYCLING OF MANURE FROM URBAN LIVESTOCK FARMS: A CASE STUDY IN ETHIOPIA

期刊论文

FULL TIME-SPACE GOVERNANCE STRATEGY AND TECHNOLOGY FOR CROPLAND NON-POINT POLLUTION CONTROL IN CHINA

期刊论文

Microplastics in municipal wastewater treatment plants: a case study of Denizli/Turkey

期刊论文

Efficiency evaluation of government investment for air pollution control in city clusters: A case from

期刊论文

Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study

期刊论文

Cyclooxygenase-2 gene-1195G/A genotype is associated with the risk of HBV-induced HCC: A case-controlstudy in Han Chinese people

Li-Feng LIU MD, PhD, Qiong CHEN MD, PhD, Ying CHANG MD, PhD, Ju-Sheng LIN MD, PhD, Jin-Liang ZHANG MM,

期刊论文

Comparison of indirect boundary element and finite element methods A case study: Shiraz-Esfahan railway

Amin MANOUCHEHRIAN, Mohammad Fatehi MARJI, Mohsen MOHEBBI

期刊论文

Classification and quantification of excavated soil and construction sludge: A case study in Wenzhou,

期刊论文

Pavement sustainability index for highway infrastructures: A case study of Maryland

Stella O. OBAZEE-IGBINEDION, Oludare OWOLABI

期刊论文

Supplier development and its incentives in infrastructure mega-projects: A case study on Hong Kong-Zhuhai-Macao

Wei ZENG, Jinwen ZHANG, Hongwei WANG, Hongtao ZHOU

期刊论文

Investigating the effect of online and offline reputation on the provision of online counseling services: A casestudy of the Internet hospitals in China

期刊论文

Causations of failure in megaprojects: A case study of the Ajaokuta Steel Plant project

Oluwole Alfred OLATUNJI

期刊论文